| County | Route | Location | Restriction | Detour |
| Anderson | I-75 | Wolf Valley Rd
| Axle Weight Restriction
| SR-170 (EB), US-441 (NB), SR-61 (WB) |
| Anderson | I-75 | Coal Creek
| Axle Weight Restriction | |
| Coffee | I-24 | Duck River
| Axle Weight Restriction | |
| | | | | |
| Decatur | I-40 | Prospect Rd
| Axle Weight Restriction | |
| Decatur | I-40 | Wolf Valley Rd
| Axle Weight Restriction | |
| Dyer | US-412 | North Folk Forked Deer River
| WB: 80,000 Pound Limit
EB: 56,000 Pound Limit
| EB: US-412, SR-210, US-51, SR-78, I-155
WB: I-155, SR-78, US-51, SR-210, US-412 |
| Giles | I-65 | Diana Rd
| Axle Weight Restriction | |
| Greene | I-81 | Norfolk Southern Rail Road
| Axle Weight Restriction | SB: US-11E, Pope Rd, E Morris Blvd, US-25E, I-81
NB: US-25E, E Morrise Blvd, Pope Rd, US-11E (Height Restricted 14'6") |
| Greene | I-81 | Pine Grove Rd
| Axle Weight Restriction | SB: US-11E, Pope Rd, E Morris Blvd, US-25E, I-81
NB: US-25E, E Morrise Blvd, Pope Rd, US-11E (Height Restricted 14'6") |
| Hamblen | I-81 | Southern Rail Road
| Axle Weight Restriction | NB: I-81, SR-341, SR-113, US-25
SB: I-81m US-11E, Pope Rd, E Morris Blvd, US-25E, SR-113, SR-341, I-81 |
| Hamblen | I-81 | Lowland Rd
| Axle Weight Restriction | SB: US-11E, Pope Rd, E Morris Blvd, US-25E, I-81
NB: US-25E, E Morrise Blvd, Pope Rd, US-11E (Height Restricted 14'6") |
| Hamblen | I-81 | Bent Creek
| Axle Weight Restriction | SB: US-11E, Pope Rd, E Morris Blvd, US-25E, I-81
NB: US-25E, E Morrise Blvd, Pope Rd, US-11E (Height Restricted 14'6") |
| Hamilton | US-27 | Daisy Dallas Rd
| Axle Weight Restriction | |
| Hamilton | SR-153 | CSX Rail Road | Axle Weight Restriction | SB: SR-153, SR-317, Jersey Pike, SR-153
NB: SR-153, Jersey Pike, SR-317, SR-153 |
| Hamilton | SR-153 | Hickory Valley Rd
| Axle Weight Restriction | |
| Hawkins | US-11W | Holston River | WB: 200,000 Pound Limit | |
| Haywood | I-40 | Hatchie River
| Axle Weight Restriction | |
| Humphreys | I-40 | Buffalo River | Axle Weight Restriction | |
| Jefferson | I-40 | French Broad River
| 130,000 Pound Limit | EB: Exit 424, SR-113, US-25W, I-40
WB: Exit 432A, US-25, SR-113, I-40 (Height Restricted 14'6")
WB: Exit 432A, US-25, SR-92, I-40 |
| Jefferson | I-81
| SR-33 | Axle Weight Restriction | |
| Jefferson | I-81
| SR-37 | Axle Weight Restriction | SB: I-81, US-11W, I-26, I-81
NB: I-81, I-26, US-11W, I-81 |
| Knox | I-640 | CSX Rail Road | Axle Weight Restriction | |
| Knox | I-640 | US-441 | Axle Weight Restriction | Ramp Off/On at Exit 6 |
| Knox | US-11W
| Loves Creek | Axle Weight Restriction | |
| Madison | US-45 Byp
| Abandoned Rail Road | Axle Weight Restriction | |
| Marion | I-24 | Squatchie River
| Axle Weight Restriction | WB: I-24, Exit 158, SR-27, US-41, SR-28, I-24
EB: I-24, Exit 155, SR-28, US-41, SR-27, I-24 |
| Marion | SR-28
| Town Creek
| Axle Weight Restriction | |
| Marion | US-72 | Battle Creek | Axle Weight Restriction | |
McMinn
| I-75 | Hiwassee River
| Axle Weight Restriction | |
| Montgomery | SR-13 | Cumberland River
| 80,000 Pound Limit | |
| Putnam | I-40 | N & E Railer Road | Axle Weight Restriction | |
| Putnam | SR-111 | Shag Rag Rd
| 80,000 Pound Limit | NB: Exit 300, US-70, SR-84, SR-111
SB: SR-84, US-70, I-40 |
| Roane | I-40 | US-27 | Axle Weight Restriction | WB: I-40, Exit 347, US-27, US-70, SR-299, I-40
EB: I-40, Exit 338, SR-299, US-70, US-27, I-40 |
| Robertson | I-65 | Red River
| Axle Weight Restriction | SB: Exit 117, SR-52, US-31W, SR-25, I-65
NB: Exit 112, SR-25, US-31W, SR-52, I-65 |
| Robertson | I-65 | South Fork Red River
| Axle Weight Restriction | SB: Exit 117, SR-52, US-31W, SR-25, I-65
NB: Exit 112, SR-25, US-31W, SR-52, I-65 |
| Shelby | I-55 | SR-175 | Axle Weight Restriction | |
| Shelby | US-51 | ICG Rail Road
| Axle Weight Restriction | |
Shelby
| I-55 | Big Creek | Axle Weight Restriction | |
| Shelby | I-55 | E Brooks Rd
| Axle Weight Restriction | Ramp Off/On at E Brooks Rd |
| Tipton | US-51 | Town Creek | Axle Weight Restriction | |